智財技轉處 Department of Intellectual Property and Technology Transfer 智財技轉處 Department of Intellectual Property and Technology Transfer

本院覽號：28A-970917

創作人：Chi-Huey Wong, Ashraf Brik, Yu-Ying Yang, Simon Ficht, Richard Payne

智財權：US 、EU、JP pending

摘要：

Chemical synthesis of peptides and proteins is a widely studied field, and methods have been developed for the syntheses of such compounds using sequential coupling reactions, particularly involving anchoring on solid phases such as polymers. However, sequential synthetic methods are not well suited for the preparation of larger peptides and proteins. For these, segment coupling methods have been developed whereby shorter peptides are joined in a controlled manner to produce larger molecules.

The invention relates to a method for forming a peptide bond between a peptide comprising a C-terminal carboxyl thioester and a sidechain-glycosyl peptide with a free N-terminal amino group wherein the sidechain-glycosyl includes a thiol group, comprising contacting the two reagents in an aqueous medium to form the coupled product via an intramolecular S to N shift of a acyl group from a thioester formed by a step of transthioesterification.

智財技轉處聯絡人：

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If you are interested in this technology, please fill in the information on the webpage under the manufacturer option (Apply for Technology Licensing, Material Transfer, or Sponsored Research) on the website of this office, and the undertaker will contact you