We have generated a monoclonal antibody (AGP3) that binds to polyethylene glycol (PEG). This antibody can be used for the detection and quantitation of PEG-modified molecules as well as for the clearance of PEG-modified molecules from the blood.
●Detection of PEG-modified molecules ●Quantitation of PEG-modified molecules ●Sensitive and specific detection of PEG-conjugates ●Rapid clearance of PEG-conjugates from blood
PEG is increasingly being employed to modify recombinant proteins and drugs for human therapy. This is due to the properties of PEG which can increase the half-life, reduce degradation, improve stability and reduce the immunogenicity of proteins and drugs. Current methods to measure PEG are relatively insensitive, require removal of biological contaminants or employ radioactively-labeled compounds. AGP3 can be employed to measure the concentration of PEG-modified compounds in convenient ELISA formats. AGP3 can be employed to detect fmol levels of PEG-protein conjugates. Such an assay is 100 to 1000 times mores sensitive than current detection methods. In addition, crude serum or biological samples can be employed. Thus, it can be used for pharmacokinetics studies to speed up the clinical development of PEG-modified drugs. AGP3 can also detect PEG-modified proteins in immunoblots as well as bind PEG-modified liposomes and nanoparticles.
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