本院覽號:28A-990503
創作人:翁啟惠、吳盈達
智財權:US 9,073,941
摘要:
發現一系列擁有6-methylpyrimido[5,4-e][1,2,4]triazine-5,7-diones, imidazo[4,5-b]quinoxaline,3-methylamino-1H-quinolin-2-one,and 1-imidazol-4-yl-sulfonyl piperidine-4-carboxamide 結構之化學分子為硫辛醯胺脫氫酶抑制化學分子,其生物活性IC50低於1uM。五倍子萃取物中(單寧(tannic)與沒食子酸(gallic acid))發現為硫辛醯胺脫氫酶抑制物。
可能的應用範圍:
肺結核病治療
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