創作人：Chi-Huey Wong, Yih-Shyun E. Cheng, Hui-Ming Yu, Ting-Jen R. Cheng
智財權：US Provisional pending
We show that the crude extract of Plectranthus Amboinicus (PA) has anti-inflammatory effects and can inhibit AP-1 binding in vitro. The incubation of HUVEC cells with PA crude extract results in significant inhibition of the LPS-induced expression of IL-6, IL-12, MCP-1, and RANTES. After the crude extract being further fractionated with a preparative HPLC, the active components can server as a novel leads for potential AP-1 inhibitors. We also identify that in vitro AP-1 binding activity can be inhibited by some fractionats from actinomycetes fermentation broth. These fractions have inhibitory effects on AP-1activity and are useful as preventive or therapeutic agents for diseases in which excessive expression or activities of AP-1 are involved.
- Novel lead
- Native Taiwanese Actinomycetes
智財技轉處聯絡人：張書銘 / 02-2787-2600 / firstname.lastname@example.org